This paper presents the protocol of two initial studies of the EASIER project, which investigates how virtual reality (VR) can enhance collaboration and learning by leveraging social and neural synchrony between physically distant individuals. To support these studies, three VR-based serious games were developed, each targeting different interaction styles and cognitive demands. Study I compares social and neural synchrony in physical and virtual settings to evaluate how presence and realism in VR influence collaboration and learning outcomes. Study II extends this investigation to four-person groups, exploring whether synchrony in VR emerges as a group-level phenomenon and identifying factors that modulate its development. Participants’ neural and psychophysiological activity, as well as subjective experience will be recorded and analyzed. The expected results aim to advance our understanding of synchrony as a mechanism for effective human interaction and offer implications for educational practices, remote teamwork, and clinical applications. Ultimately, this research may inform the design of inclusive, human-centered virtual environments that foster deeper engagement, cooperation, and social connection.