Anipemza, in Shirak province, is located on the border of Armenia with Turkey, on the bank of the Akhurian River. On the opposite coast, there are, not so far, the ruins of the ancient and famous Armenian city of Ani in Turkey. The old Anipemza, founded in the fourteenth century by Kamsarakan princes, is a village and rural community (municipality) of Armenia. Anipemza’s territory is mainly well known for the nearby ruins of the Yererouik Basilica of the fourth-fifth century and its quarry. An urban layout of particular interest characterises the “new” village, and the impression is that it is in a workers’ village of the early twentieth century. Near the buildings, a wide-open quarry can be seen to extract the tuff and pumice. We cannot exclude the fact that the Yererouik basilica was built with the tuff of this quarry. The oral witness obtained by interviewing the residents has established that the new Anipemza, since 1926, was a village for the orphans of the 1915 genocide and then has also been a penal colony for forced labour for the dissidents of the Soviet regime in Armenia. The main problems in the area are mainly the lack of work for the inhabitants, repair of the water supply system, lack of bathrooms, preservation and enhancement of the buildings, repair of road paving, agricultural products sales and completion of natural gas infrastructures. However, the exceptionally high urban and architectural quality of Anipemza deserves a contribution to make it known, expecting it to be preserved and enhanced. Research and proposals for conservation, reuse, and touristic-economic improvement in Anipemza’s area, which started in 2013 by the authors of this paper, are still in progress.