Ceramic membranes are becoming increasingly popular in water treatment due to their remarkable tolerance for intense cleaning options with severely fouled membranes in comparison to their polymeric membrane counterparts. Despite their robust capacity, there is a lack of research on the mitigation of ceramic membrane fouling with chemically enhanced backwash (CEB) methods. CEB uses a low-concentration chemical solution to dislodge and remove foulants in place of, or in addition to, a conventional backwash procedure which enables a longer membrane filtration duration before a more in-depth clean-in-place step is required. This research examined the use of Tween 80, a non-ionic surfactant, with NaOH + NaOCl and carbon dioxide (CO2) as novel CEB solutions for foulant removal. While the carbon dioxide clean was not effective, Tween 80 (polysorbate 80), which is a versatile emulsifier produced encouraging outcomes. This study found that the transmembrane pressure (TMP) of Tween 80 + NaOH + NaOCl compared to hydraulic backwash after multiple filtration cycles was 84.46 kPa over 129.73 kPa. Resistance-in-series (RIS) evaluation showed that Tween 80 in conjunction with NaOH + NaOCl reduced irreversible fouling from 2.30E+12 m−1 to 1.12E+12 m−1 compared to a hydraulic backwash. This study emphasizes surfactant selection in CEB, examining its effects on zeta potential and water quality parameters. It also shows how surfactant-driven techniques might improve ceramic membrane filtration and promote sustainable water treatment.