The adaptation of the built environment to climate change requires strategic interventions that enhance urban resilience against increasing environmental risks. Adaptation measures emphasize targeted solutions to minimize climate-related vulnerabilities. Among these, Nature-Based Solutions (NBS), such as green roofs and vegetated facades, play a crucial role in improving thermal regulation, storm water management, and urban biodiversity. However, their effectiveness depends on large-scale implementation guided by systematic evaluation criteria rather than isolated applications. This study presents a methodological framework for assessing buildings’ suitability for green roof implementation, integrating technical feasibility, environmental impact, and economic viability. The approach consists of defining intervention areas, categorizing relevant parameters, and prioritizing buildings through a multi-criteria evaluation model. Advanced tools, including Geographic Information Systems (GIS) and environmental modeling, support data-driven decision-making. A structured weighting system, based on literature review, field observations, and expert consultations, ensures an objective evaluation of key feasibility indicators such as structural capacity, roof conditions, and accessibility. The methodology facilitates the identification of high-priority buildings where green roofs can be most effectively implemented, optimizing both environmental benefits and economic investments. By providing a scalable decision-support tool, this study contributes to advancing climate adaptation strategies and promoting sustainable urban transformations. The proposed methodology is applied on a case-study area in the city of Naples (Italy).