Telemedicine offers numerous advantages, particularly in enhancing access to healthcare in rural and remote areas where medical facilities are limited. However, its effectiveness is challenged by issues such as communication problems, information security concerns, and uncertainties regarding the quality of care compared to traditional face-to-face consultations. This study reviews the growing adoption of telemedicine in healthcare, emphasizing the various challenges that could impede its success. A critical gap is the lack of comprehensive data on the current state of telemedicine in Malaysia, especially when compared to face-to-face consultations. This data scarcity hinders the advancement of telemedicine services, leaving concerns about the inconsistent quality of care, patient reluctance due to doubts about its effectiveness, and the potential exacerbation of health disparities unaddressed. The study employs the Unified Theory of Acceptance and Use of Technology (UTAUT) model to assess the determinants influencing the adoption of telemedicine. Through a comparative analysis, this study aims to explore these issues, focusing on patient satisfaction, clinical effectiveness, and economic impact, to provide insights for improving telemedicine practices in Malaysia.