The architecture of an intelligent microclimate control system for an industrial enterprise based on the principle of synergy is proposed, which will help to increase the efficiency of production in variable operating conditions of production premises. The purpose of the study is to develop a structure, mathematical support and appropriate algorithms for an intelligent microclimate control system in production, which provides an optimal microclimate at large manufacturing enterprise. The integration of industrial air conditioners into cyber-physical system of an industrial enterprise will ensure an increase in the efficiency of the climate equipment functioning through using modern principles of multidimensional control and adequate mathematical models of industrial air conditioning.