The Clemente course has its international base in the United States, with courses offered on the east and west coast, from California to New York. The course is also run in Canada, South Korea, Argentina and Australia. For more than 30 years, Clemente has supported marginalised and disadvantaged people to access university education. Aiming to break the cycle of poverty, social injustice and inequality, Clemente can -and does—change the lives of disadvantaged people and allows them to re-engage with society by studying the humanities in a supportive environment. In the education sector, First Nation people are the most disadvantaged group, from primary school through to high school; those who pursue a tertiary education face additional difficulty. Across the world, education systems are failing First Nation peoples, and as time progresses the number of First Nation students enrolled in education continues to fall. This has far-reaching consequences such as contributing to the loss of First Nation culture and the extinction of First Nation languages. This chapter examines the barriers faced by First Nation people when it comes to education and discusses how the Clemente course can, and does, transform the lives of First Nation students.