This chapter is designed to satisfactorily expose the general medical practitioner (the focus of this book) to conditions that affect hair, sweat glands, sebaceous glands, and nails. The conditions that were selected and are included in the chapter are alopecia, hidradenitis suppurativa, subungual hemorrhage with hematoma, acne vulgaris, onychomycosis and paronychia, and onychomadesis. The skin would not really be skin without its appendages. It is, therefore, expedient for the reader to try to familiarize themselves with diseases that affect these adjuncts of the skin. The appendages and their distribution are of importance and that is why males who are hairy would be very concerned about developing baldness or alopecia at a very early age. In the same vein, a 13-year-old will hardly have a psychological component associated with acne vulgaris since they are aware of many teens that have the same skin condition; if, however, they still have significant acne vulgaris at age 29, it is very likely to be bothersome. For the same reason, hirsutism is a challenge for adults of the female gender. Nails, particularly, fingernails, are parts of the body that are not only very visible but also a focus of beauty and finesse in care of the skin. Traumatic subungual hemorrhage may affect work.