Non-human animals are agency-bearing beings that have the capacity to establish ties in emotional relationships with people. Across time and space, there have been diverse interactions in which those agents co-modeled their bonds. The traditional view of relations between humans and non-human animals, centered on economic utility, has been superseded by studies that account for the links from social, emotional, identity-based, among other perspectives. In this chapter, an overview of the ways in which the interactions between non-human animals and people have been assessed from a zooarchaeological perspective is presented. The analytical topics defined include the role of non-human animals in: (a) the interactions and circulations of goods; (b) the construction of dwelled landscapes; (c) the healing and transmuting practices; (d) the construction and sharing identities and memories; (e) the social values of food and (f) the relationship as companion species. This study emphasizes the contributions that Archaeology and particularly Zooarchaeology can make to the study of human-non-human relationships, by providing time depth, a diachronic perspective, and diversity of social groups across their environments. Although multidisciplinary approaches are numerous, we make a call for reinforcing the transdisciplinary projects by integrating and generating fluid dialogue between archaeological research and other humanities.