Additive manufacturingAdditive Manufacturing (AM) (AM), also known as 3D printing3D printing, is today a widely used technology in the fabrication of complex-shaped biomaterialsBiomaterials from Digital computer-aided (CAD) designsDigital computer-aided (CAD) design. In this context, 3D fabrication responds to the increasing demand for new scaffoldsScaffold with tailor-made architecturesArchitecture with the potentialPotential forTissue regeneration tissue regenerationRegeneration, including structures specially designed for the vascularization of scaffolds. This chapter aims to provide an overview of the state-of-the-art, currentCurrent, and future perspectives in the field of biomaterials AM with their actual technological limitations and biovalidation strategies, i.e., from the manufacturing process technology to the direct biomedical applicationsBiomedical application. Up until now, AM can also improve prostheticsProsthetic with biometric characteristics with patient-specific anatomical data or facilitate the creation of a new organOrgan (liver, lymphoid organs). Another application is in vitro drugDrug testing (liberation studies, etc.) with 3D-printed modelsModel of anatomical parts. So far, the latest advances reveal that materialMaterial selection and AM printing technologyAM printing technology are the most critical factors in achieving the most clinical success rate according to the patient’s needs. Moreover, AM of compositeComposite materialsMaterial stands as a promising strategy for many applicationsApplications, but still there are fundamental relationships between printing, pre-treatment, and post-treatment parameters of each biomaterial for clinical use have to be established. Notwithstanding, although 4D printing4D Printing has been targeted as the future direction, more studies for its application in the biomedical field have to be implemented.