The management of cardiac patients requiring ventilator or oxygenation support often requires home-based care models, presenting both opportunities and challenges for modern healthcare systems. This chapter provides a comprehensive exploration of home care and discharge models for this complex patient population, addressing the multifaceted aspects of their care outside traditional hospital settings. It begins by examining the prevalence of home mechanical ventilation and types of cardiac disorders necessitating home respiratory support. It discusses the epidemiology of home mechanical ventilation, noting the variability in prevalence across different healthcare systems and geographical regions. Various home care models are explored, including nurse-led care, physician-supervised monitoring systems, and hospital-at-home programs. The chapter underlines the critical role of telemedicine and remote monitoring technologies in revolutionizing home care for ventilator-dependent cardiac patients. The importance of multidisciplinary team involvement and comprehensive patient and caregiver education is highlighted as fundamental to successful home care implementation. Effective discharge planning is identified as a crucial element in ensuring continuity of care and optimal outcomes. Key components of discharge planning, strategies for addressing potential barriers to successful transitions, and the importance of ongoing follow-up care are emphasized. Ethical considerations, such as balancing quality of life with longevity and equitable resource allocation, are discussed in the context of home ventilation for cardiac patients. The chapter also addresses current challenges in implementing home care models, including healthcare system readiness, workforce shortages, and technological limitations. By providing this overview, this chapter aims to equip healthcare professionals with the knowledge to improve patient outcomes through effectively implementing home care and discharge models for ventilator-dependent cardiac patients.