The utilization of non-invasive ventilation (NIV) is increasingly being recognized as advantageous in both the intraoperative and postoperative management of cardiac procedures. Extensive research has been conducted on the post-surgical application of non-invasive ventilation following cardiac surgeries, with demonstrated effectiveness. It is well known that atelectasis and cardiogenic pulmonary edema frequently manifest after cardiac surgeries. By employing prophylactic NIV immediately after cardiac surgery, specifically in post-cardiac subjects who have undergone procedures such as coronary artery bypass surgery, the occurrence of post-extubation acute respiratory failure (ARF) can potentially be prevented. Furthermore, this intervention has the potential to decrease reintubation rates and reduce both the length of hospital stays and stays in the intensive care unit (ICU). In patients with orthopneic cardiac conditions necessitating transesophageal echocardiography (TEE), the utilization of NIV can diminishes the requirement for profound sedation or general anesthesia. When undergoing percutaneous aortic valve implantation (PAVI), individuals classified as high-risk derive noteworthy benefits from the implementation of minimally invasive anesthetic techniques. However, when local anesthesia is employed, a significant challenge arises as the patient is required to maintain a supine position on the catheterization laboratory table, a position that an awake and orthopneic patient can barely endure; under these circumstances, a state of light sedation must be induced. It is important to note that the administration of sedatives carries the inherent risk of respiratory depression. The utilization of NIV serves to circumvent the complications associated with general anesthesia while simultaneously preserving sufficient ventilation during light sedation. NIV is emerging in conjunction with other interventional cardiology techniques, such as percutaneous closure of the left atrial appendage (LAA) and isolation of the pulmonary veins for the treatment of atrial fibrillation. The field of electrophysiology (EP) is continuously expanding, presenting increasing levels of complexity. The insertion of pacemakers and implantable cardioverter defibrillators (ICDs) is commonly performed in patients with heart failure, necessitating sedation that may require the utilization of non-invasive ventilation.