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Restenosis often causes failure in percutaneous coronary intervention. Drug-eluting stents (DES) are effective in mitigating this issue. This study aimed to fabricate sirolimus (an antiproliferative drug)-eluting stents and investigate drug release from the stents. INA-Stents were coated with a combination of sirolimus and collagen (a biodegradable polymer) using three different forward speeds (7–9 mm/s) of the ultrasonic airbrush spray. Alternate coatings of 10 layers of sirolimus and 11 layers of collagen were implemented in the DES to reduce post-implantation thrombosis and ensure controlled drug release, respectively. Among the fabricated DES, stents produced using the lowest forward speed (INA-Stent A) exhibited the thickest coating (around 317–490 nm) and the most consistent sirolimus release. All three stents released the drug at the rates of approximately 0.60–0.72 mg/day. These findings suggest that INA-stent A may be the most optimal design for the DES.

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Engineering Time Release from Sirolimus-Eluting Stents

  • 会议论文

  • 发表日期：

    2025年

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  • Chandra Pratiwi,
  • Heribertus Dedy Kusuma Yulianto,
  • Eka Noviana,
  • Adhyatmika,
  • Dyah Listyarifah,
  • Widowati Siswomihardjo,
  • Alva Edy Tontowi,
  • Nahar Taufiq,
  • Dinar Arifianto,
  • Setiyo Budhi

摘要

Restenosis often causes failure in percutaneous coronary intervention. Drug-eluting stents (DES) are effective in mitigating this issue. This study aimed to fabricate sirolimus (an antiproliferative drug)-eluting stents and investigate drug release from the stents. INA-Stents were coated with a combination of sirolimus and collagen (a biodegradable polymer) using three different forward speeds (7–9 mm/s) of the ultrasonic airbrush spray. Alternate coatings of 10 layers of sirolimus and 11 layers of collagen were implemented in the DES to reduce post-implantation thrombosis and ensure controlled drug release, respectively. Among the fabricated DES, stents produced using the lowest forward speed (INA-Stent A) exhibited the thickest coating (around 317–490 nm) and the most consistent sirolimus release. All three stents released the drug at the rates of approximately 0.60–0.72 mg/day. These findings suggest that INA-stent A may be the most optimal design for the DES.