The relationship between domesticated cattle and large carnivores in Africa concerns two main predators, the African lion and African leopard, and to a lesser extent hyenas, wild dogs, and cheetahs, all of which are considered charismatic wildlife. African domestic cattle are descended from both taurine and indicine breeds. This chapter examines this relationship between domestic cattle and these predators, and recent geomatics-based research on these ecological and agricultural issues. In terms of interspecies relationships, lions, the largest predator, prey on all sizes of cattle, while leopards, hyenas, and other smaller predators take mostly calves, sheep, and goats. The lion is unique in being a well-organized, social hunter; hence, it is capable of killing the largest cattle breeds, even those approximating the wild buffalo in size. Cattle herding is mostly practiced in savanna regions outside the forest, including Guinea, Sudan, and Sahel savanna belts in terms of declining rainfall, and cattle may be susceptible to some diseases of the moist forests. As in other continents, there is a conflict between conservation of large carnivores and expanding cattle herding, with added problems emerging from desertification, deforestation, and human population increase and generally higher levels of human poverty than in other continents. Conservation issues are gaining ground, partly fueled by increasing international interest in predator and other large mammal issues, as well as desertification, savanna ecosystem protection, and deforestation. Considering the large number of characteristic wild species, and the international interest in the large savanna protected areas such as Tsavo, Serengeti, and Kruger, Africa may also be seen as a conservation and agricultural development role model for global conservation and development issues.