The Asian continent has the largest number of predatory species capable of killing domestic cattle, including tigers, leopards, snow leopards, brown and black bears, wolves and dholes, and occasionally crocodiles. Northwestern Asia is similar to Europe in carnivore species, namely brown bears and wolves, but eastern Asia includes the tiger, leopard, and snow leopard, and tropical Asia includes dholes and black bears. There are also semi-domesticated cattle, such as the gayal, and domesticated water buffalo and yak, as well as more domesticated breeds, such as the zebu. This chapter examines the factors for large predator interactions with semi-domesticated and domesticated cattle. Current evidence indicates that very significant conflicts exist between large predators and cattle managers, especially at the local and individuals. Other conflicts have emerged between political elites and the local cattle herders, over the contradictions between the conservation of large predators and the ownership of cattle, in farms, free-ranging areas, and protected areas. Such conflicts vary regionally, especially between northern Asia, south and southeast Asia, and southwestern Asia. Political, legal, economic, sociocultural, and ecological issues have reshaped the dialogue and applications around large predators and cattle/human relations. The charismatic tiger and its ecology stand as possibly the most important dynamic in this complex scenario, especially in South Asia. It is concluded that despite significant, unresolved matters, predator-cattle issues are increasingly, effectively managed.