Wild cattle, in some cases ancestors of domestic cattle, exhibit differences in behavior and appearance between species, but also share important similarities, including large horns and a muscular body structure, social herding and defense strategies against large carnivores, aggressive behavior against threatening intruders, and apex or near apex status compared to carnivores and other herbivores. The relationship between wild cattle and large carnivores is an important backdrop to the relationship between these carnivores and domestic cattle, which are typically smaller, less aggressive, and smaller horned and are therefore easier to kill than their wild counterparts. However, few studies have compared the status of wild cattle and their domesticated offspring in terms of their strength and ability to compete with large carnivores in increasingly human-dominated landscapes. This chapter presents relevant information on all existing wild cattle species and identifies differences and similarities between species and with natural predators. Geomatics technology, which has recently emerged as a leading method for environmental assessment, is also discussed as a tool for habitat and species analysis and predictive modeling. Although the largest species of wild cattle are generally hunted only by the largest apex predators such as brown bears, tigers, and lions, comparatively smaller species of cattle and younger specimens of the large species can be killed by medium-sized predators such as leopards, cougars, wolves, and the smaller Asian and American bears. All wild cattle are social or semi-social and cooperate in defense. Some are highly intelligent in such methods and have strategic defensive measures such as teamwork in rescue efforts and guarding, as well as defending less powerful herd members. Dominance hierarchies can exist between wild and domestic cattle, with the former generally being dominant over the latter and better able to defend themselves against large carnivores. However, the behavioral characteristics of wild cattle can also be seen in domestic cattle. These questions contribute to understanding the interactions between domestic cattle and large carnivores.