Approximately 20% of lesions treated with PCI involve bifurcated lesions. These procedures are frequently complex and present significant challenges. Coronary bifurcation lesions are characterized by their location at or near a major SB (with a diameter of at least 2.5 mm), where the artery splits into two primary segments: the MV and the SB. The Medina classification remains the most widely adopted system for defining bifurcation lesions. Although PS is sufficient for most cases, certain scenarios may require a two-stent approach. Intracoronary imaging techniques are highly recommended to mitigate risks such as stent under-expansion, malapposition, and subsequent MACE.