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Centromere DNA and proteins are rapidly evolving despite their essential conserved functions in chromosome segregation. Centromere drive theory is based on the idea that centromere DNA are rapidly evolving to bias their transmission through female meiosis with associated fitness costs, which facilitate the evolution of the rest of the genome, especially the genes encoding centromere proteins to suppress the cheating and restore fitness. While the cell biological mechanisms of centromere drive and the rapid evolution of centromere proteins have been investigated and discussed, the exact nature of fitness costs associated with centromere drive remains largely unknown. In this chapter, we discuss different possibilities of fitness costs associated with centromere drive, especially focusing on how selfish centromeres can cause chromosome mis-segregation in mitosis and meiosis.

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What Are the Fitness Costs of Centromere Drive?

  • 章节

  • 发表日期：

    2025年

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  • Bo Pan,
  • Takashi Akera

摘要

Centromere DNA and proteins are rapidly evolving despite their essential conserved functions in chromosome segregation. Centromere drive theory is based on the idea that centromere DNA are rapidly evolving to bias their transmission through female meiosis with associated fitness costs, which facilitate the evolution of the rest of the genome, especially the genes encoding centromere proteins to suppress the cheating and restore fitness. While the cell biological mechanisms of centromere drive and the rapid evolution of centromere proteins have been investigated and discussed, the exact nature of fitness costs associated with centromere drive remains largely unknown. In this chapter, we discuss different possibilities of fitness costs associated with centromere drive, especially focusing on how selfish centromeres can cause chromosome mis-segregation in mitosis and meiosis.