On December 31, 2019, the World Health Organization (WHO) received the first report of Corona Virus Disease 2019 (COVID-19) from Wuhan city, China. Despite the fact that Chinese cities implemented lockdowns to restrict the spread of infection, the measures were ineffective, and the disease has since spread around the world. As a result, the WHO announced COVID-19, a global pandemic on the month of March 2020. Initially, this unforeseen global pandemic caused chaos on almost every sphere of human life. Since the first reported case of COVID-19, the world was experiencing successive waves. On 24 November 2021, a new SARS-CoV-2 variant was reported to WHO from South Africa. The new variant (B.1.1.529) was officially named Omicron (the fifteenth Greek alphabet), as a Variant of Concern. The rapid spread of this highly mutated strain across six continents in less than a week sparked a global health alarm. Since its discovery, Omicron was identified in many countries in six continents. When compared to the previous variants of SARS-CoV-2: Alpha, Beta, Gamma, Delta, Omicron was found to be the most prominent variant and distinct from the millions of SARS-CoV-2 genomes. Comparing to the Wuhan variant, it has 6 mutations which led to its increased transmissibility and vaccine resistance. The aggressive surge of Omicron made it the major corona virus strain, displacing the worldwide prevalent delta form. However, omicron was expected to be highly transmissible, it was unclear whether it was really higher transmissible than delta.