This chapter provides a review of the data regarding the friendships, romantic relationships, and risky sexual behavior of adolescents with ADHD. It offers information as well as recommendations for parents, caregivers, teachers, and clinicians caring for adolescents with ADHD. Additionally, it provides guidance on incorporating therapy to strengthen social skills that will help adolescents with ADHD build solid friendships and romantic relationships and prevent risky sexual behavior, which has been associated with poor sexual health outcomes as well as both victimization and perpetration of violence. Individuals working with and caring for adolescents and young adults with ADHD should discuss the increased risks associated with their condition and prepare them by offering resources such as psychotherapy and medication to promote healthy relationship building into adulthood.