Evaluation of the fetal face during the first trimester of pregnancy is a relatively new area of research in Fetal Medicine. The first attempts to examine the fetal face in early pregnancy were performed using transvaginal or transabdominal embryofetoscopy in the early 1990s (Cullen et al. Am J Obstet Gynecol. 162:82–6, 1990; Reece, Curr Opin Obstet Gynecol. 4:447–55, 1992; Pennehouat et al. Lancet. 340:429, 1992). Although this invasive technique allowed the early diagnosis of facial abnormalities in several high-risk cases (Dommergues et al. Prenat Diagn. 15:378–81, 1995; Ville et al. Ultrasound Obstet Gynecol. 8:11–5, 1996), the high rate of miscarriage made this approach unacceptable for diagnostic and therapeutic purposes in ongoing pregnancies (Reece, Semin Perinatol. 23:424–33, 1999). Currently, the use of this technique is confined to confirming ultrasound diagnosis before first-trimester termination of pregnancy (Tonni et al. Taiwan J Obstet Gynecol. 54:608–11, 2015).