Since the face develops at the same time and in close contact with the brain, it is expected that at least some of the anomalies and defects affecting the face will affect also the brain and vice versa. Some of them are being diagnosed during fetal life and will be presented in this chapter. We will describe the possible associations between fetal facial and brain defects at each stage of brain development starting from neurulation and until the first steps of myelination (Volpe JJ, Neural tube formation and prosencephalic development. In: Neurology of the newborn. Saunders Company, Philadelphia, pp 3–50, 2008).