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During embryogenesis, the development of the lips and palate occurs at an early stage for the lips (by week 4 of gestation), whereas the primary palate fuses between 4 and 6 weeks and the secondary palate between 8 and 12 weeks. Cleft lip (CL) is the result of failure of the maxillary process to close with the medial nasal prominence, while a cleft in the secondary palate is the result of failure of the palatine process to elevate or grow [1]. Cleft palate (CP) originates at the uvula, causing uvula bifida, and progresses along the midline involving the soft palate or both the soft palate and the hard palate; in addition, a cleft lip and cleft palate (CLP) starts at the lip and continues backward involving the alveolus, the hard, and the soft palate [2].

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Orofacial Clefts in the Fetus: What We Know and What We Should Know

  • 章节

  • 发表日期：

    2025年

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  • Gabriele Tonni,
  • Waldo Sepulveda,
  • Amy E. Wong

摘要

During embryogenesis, the development of the lips and palate occurs at an early stage for the lips (by week 4 of gestation), whereas the primary palate fuses between 4 and 6 weeks and the secondary palate between 8 and 12 weeks. Cleft lip (CL) is the result of failure of the maxillary process to close with the medial nasal prominence, while a cleft in the secondary palate is the result of failure of the palatine process to elevate or grow [1]. Cleft palate (CP) originates at the uvula, causing uvula bifida, and progresses along the midline involving the soft palate or both the soft palate and the hard palate; in addition, a cleft lip and cleft palate (CLP) starts at the lip and continues backward involving the alveolus, the hard, and the soft palate [2].