The spectrum of conventional CT- and MR-guided punctures is enlarged by navigated computer-assisted puncture techniques. The 3D-guided puncture technique provides a more sophisticated planning of the percutaneous path because the puncture plane can be selected individually in 3D. Multimodal fusion imaging data for diagnostic and planning purposes, and fusion of postoperative data to the initial planning data, may be included. Rigid aiming devices enhance puncture accuracy and patient safety and reduce radiation dose and OR time. Based on the advantages of navigated interventions and the large multipurpose applicability, navigation systems may represent a valuable investigation for an institution.