In case of cerebrospinal fluid (CSF) leakage, pharmacological therapy with caffeine may help in some cases. Surgical occlusion of the leakage is an invasive option. In contrast, local application of blood is a very effective method to treat CSF leakage with peridural adhesions producing the desired result. Taking into account risks and complications, the indication should be clearly defined. Therapy should be performed by an experienced interventionalist.