Various imaging modalities are used for pre-, peri-, and postinterventional imaging as well as follow-up. The choice of the best imaging technique to visualize the lesion and the interventional materials has to be made on a case-by-case basis. This decision is key for the safety and success of the procedure. CT is widely accessible and provides an excellent overview with the capability of three-dimensional reconstructions based on volumetric data sets. In addition, intestinal or vascular structures can be clearly identified using iodinated contrast material. CT is often the most suitable imaging modality for thoracic and abdominal procedures. MR imaging has specific advantages, such as its lack of ionizing radiation. When compared with CT, it provides a similar overview with a better soft-tissue contrast and the inherent ability to acquire images in arbitrary planes. It holds the potential to measure physiologic parameters like flow, temperature, and cardiac function. However, high costs, the need for a special environment, and impaired patient accessibility limit its clinical use. As a consequence, the use of MR-guided interventions beyond biopsy of the breast or prostate is still limited to a few centers.