Every worker must return home safely, in good health and with good energy from the workplace. Therefore, new approaches to ensuring occupational health and safety must be developed. Sustainable Occupational Safety and Health (SOSH) represents a novel workplace safety, health, and personnel management paradigm. It emphasizes the importance of workers’ long-term, sustainable well-being, fostering regeneration and revitalization in occupational safety and health (OSH). By incorporating the SOSH practices into organizations’ vision, mission and employee value proposition, and—most importantly—their implementation, regular periodical reviewing and updating, organizations from the private and the public sectors can cultivate distinctive and appealing employer brands, attracting and retaining top talents. SOSH treats people as humans and highlights their sustainable safety, health, and well-being. SOSH contributes to sustainable organizations through the sustainable development of employees. It also comprises other concepts, including employees’ safety, health, well-being, justice, participation, employability, etc. The knowledge-cum-values management approach to the OSH, supported by sustainability and social responsibility (Štrukelj et al., Social responsibility and corporate governance: volume 2: policy and practice. Springer, Cham, 2021; Zlatanović and Mulej, Baltic J Manage 10:497–518, 2015), Dialectical systems theory, coupled with its law of requisite holism, serves as the theoretical foundation for the emergence of SOSH. This distinctive conceptual framework, absent from extant literature, holds significant importance within the ISSR society.