The increasing generation of solid waste presents a significant challenge today. Understanding the biochemical composition of waste and exploring its potential applications, including the recovery of biomolecules and bioactive compounds, offers valuable insights for the effective management of this biomass. Identifying sustainable strategies for managing organic waste aligns with the principles of the circular economy, where waste is recognized as a resource and transformed into raw material for subsequent processes. This review focuses on waste from avocados, jackfruit, and apples, originating from both industrial processing and household consumption. It examines the types of waste generated, their botanical correlations, and the potential of each type of waste to provide macromolecules such as proteins, enzymes, carbohydrates, and lipids, as well as bioactive compounds like polyphenols, known for their significant antioxidant and antimicrobial properties. Furthermore, the review discusses the complete utilization of these fruits for food production, composting, and biotechnological applications. The generation of new compounds from these waste materials offers innovative and enhanced alternatives for the continuation of fruit production chains.