Total joint replacement surgery is an effective treatment for severe joint diseases, while finite element simulation can effectively predict the mechanical performance of artificial joints, providing important references for surgical planning optimization and prosthesis design. However, in finite element simulations of artificial joints, when applying loading conditions defined by international standard testing machines, coupling effects exist among rotational loads in three orthogonal directions. This phenomenon leads to deviations between the actual loading patterns and predefined requirements, consequently affecting the accuracy of simulation results. To enhance the reliability of finite element simulations for artificial joints, this study focuses on optimizing the application of rotational loads. By analyzing the influence of coupling effects under different loading conditions, we aim to explore optimal loading strategies to minimize errors induced by coupling effects to the greatest extent. This study focuses on artificial hip joints as the specific research subject, employing finite element simulation methods to analyze prosthesis wear and compare simulation results under different loading sequences. The research results demonstrate that the application of combined internal-external rotation and flexion-extension loading can significantly reduce the influence of rotational coupling effects and improve the accuracy of simulation results. This study provides new insights for standardizing and refining finite element simulations of artificial joints, which holds significant implications for enhancing prosthesis design and improving surgical success rates.