The global climate problem is increasingly serious, and carbon neutrality has become an international hot issue. CO2 geological storage technology is regarded as one of the most potential means of carbon emission reduction. In the process of geological storage, CO2 injection will lead to the accumulation and propagation of pressure, which will lead to the accumulation of pressure at the bottom of the cap rock. In serious cases, it will lead to the rupture of the cap rock, threatening the safety of CO2 geological storage projects. In this study, considering the complexity and heterogeneity of the actual geological conditions, three-dimensional geological models with inclined and heterogeneous formations were constructed respectively, and the effects of inclined and heterogeneous formations on the evolution of CO2 plume and pressure accumulation were explored. The results show that the increase of formation tilt angle and the aspect ratio of reservoir permeability will lead to the expansion of plume migration range by at least 30%, and the pressure accumulation at the bottom of the cap rock is about 1.5 times of the original formation pressure. In addition, the reservoir thickness has a significant impact on the pressure accumulation at the bottom of the cap rock. It is suggested that the reservoir with a thickness greater than 40 m should be given priority in the site selection of CCUS project to reduce the risk of failure of the integrity of the cap rock. The research can provide reference for the CO2 geological storage project to be carried out on a large scale in China.