As discussed in earlier chapters, plastic pollution is a critical environmental issue requiring strong scientific, technological, and policy responses. This chapter provides an overview of plastic waste mitigation, starting with the global challenge of measuring plastic pollution across various environments. It highlights advancements in recycling technologies and ongoing research aimed at enhancing efficiency and scalability. Strategies for addressing plastic waste, including physical, chemical, and biological methods, are assessed. The chapter also discusses the circular economy as a framework for reducing plastic dependency and promoting sustainable practices, alongside practical policy recommendations for stakeholders. Ultimately, it underscores the need for integrated efforts in science, technology, and policy to effectively address the plastic pollution crisis.