Human resource is one of the four resources of enterprises. Excellent human resource management can enhance the internal cohesion and centripetal force of enterprises, reduce the mobility of employees and internal friction of enterprises, and help enterprises survive and develop in the fierce market competition. The construction of honesty culture is the key to the service and management of human resources. This paper will analyse how to construct the integrity system in enterprise human resources service. In This paper, honesty culture is integrated into the construction of enterprise human resource management information system, including organizational management, recruitment management, performance management, salary management, training management and staff management. Through the actual operation results, it shows that the new system is significantly improved compared with the traditional system in terms of stability, user satisfaction, system ease of use, fairness perception, integrity training participation, performance evaluation fairness, query response time and the incidence of dishonest behaviour.