Artificial Intelligence (AI) has emerged as a transformative force in contemporary business, reshaping work practices through automation, enhanced decision-making, and improved performance. However, this technological transition brings forth significant challenges, particularly the imperative to preserve humanity and meaning within organizations. In response, workplace spirituality has emerged as a vital framework that fosters environments where individuals flourish by aligning personal values with organizational objectives. Human Resource Management (HRM) occupies a crucial position in navigating this complex intersection, tasked with the integration of AI in ways that prioritize employee well-being, job satisfaction, and a cohesive organizational culture. This paper investigates how HRM can harmonize the technological advancements of AI with the human and spiritual dimensions of work. Through the application of case studies, academic research, and empirical evidence, it offers actionable recommendations for HR professionals aimed at creating workplaces that balance technological innovation with spiritual growth, thereby ensuring a holistic and meaningful work experience.