This chapter explores crosscutting issues and comparative insights into eight case studies of international joint universities located in Asia and the Middle East. The focus is on their establishment, co-founders and funders, driving rationales, joint governance, academic programs, research, and international engagement. The analysis identifies three co-founding partnership models (institution-to-institution, government-to-government, private–public collaborations) and examines the implications of host and foreign partner country variations in funding mechanisms and regulations. It highlights the critical role of international joint universities in fostering innovation, enhancing research capacity, and promoting socioeconomic development in host countries. Despite shared challenges, such as sustainability of funding, cross-cultural complexities, changing priorities, and pressing global needs such as climate change, food security, and epidemics, international joint universities remain pivotal in addressing these issues. This chapter concludes with a reflection on both the benefits and potential risks of international joint universities in the evolving landscape of international higher education partnerships.