In patients with LV dysfunction, multimodality imaging offers the opportunity to obtain continued information on regional and global cardiac function, myocardial viability, coronary anatomy, and regional relative or absolute myocardial perfusion. The different modalities may be performed separately and integrated/fused afterward (i.e. through hybrid imaging) or may be used in a single-step approach to defining HF etiology, the extent and severity of myocardial damage/ischemia, indicate and predict the response to targeted treatments (i.e. CRT, coronary revascularization) as well as to perform pre-interventional assessment (i.e. to program trans-catheter ablation of arrhythmias or valvular interventions.