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This paper presents the study of the effects of Huntington’s disease (HD) on the mechanical and electrical properties of mouse red blood cells (RBCs). Electro-deformation spectroscopy (EDS), a biomechanical assay we recently developed and validated with human RBCs, is used to measure the mechanical performance of mouse RBCs, including cell deformation and fatigue resistance. Cell electrical and mechanical parameters, such as membrane permittivity, cytoplasm conductivity, and shear modulus, are further extracted using a custom MATLAB code using the frequency-dependent major and minor axes of stretched cells. Comparisons between HD and wildtype groups revealed differences in weight growth and deformation patterns with aging. HD mice struggled to gain weight, and their RBCs show lower deformability (higher membrane shear modulus) and higher cytoplasm conductivity. The findings suggest that HD alters the mechanical and electrical properties of RBCs with potential implications for tracking the disease progression.

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Effect of Huntington’s Disease on Electrical and Mechanical Properties of Red Blood Cells in a Mouse Model

  • 会议论文

  • 发表日期：

    2025年

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  • Liliana Ponkratova,
  • E Du,
  • Hongyuan Xu,
  • Jianning Wei

摘要

This paper presents the study of the effects of Huntington’s disease (HD) on the mechanical and electrical properties of mouse red blood cells (RBCs). Electro-deformation spectroscopy (EDS), a biomechanical assay we recently developed and validated with human RBCs, is used to measure the mechanical performance of mouse RBCs, including cell deformation and fatigue resistance. Cell electrical and mechanical parameters, such as membrane permittivity, cytoplasm conductivity, and shear modulus, are further extracted using a custom MATLAB code using the frequency-dependent major and minor axes of stretched cells. Comparisons between HD and wildtype groups revealed differences in weight growth and deformation patterns with aging. HD mice struggled to gain weight, and their RBCs show lower deformability (higher membrane shear modulus) and higher cytoplasm conductivity. The findings suggest that HD alters the mechanical and electrical properties of RBCs with potential implications for tracking the disease progression.