Diabetes mellitus significantly compromises bone health, increasing the risk of fractures, osteoporosis, and limb amputations due to metabolic dysfunctions. Effective bone regeneration is critical for managing complex fractures and bone-related complications, with over two million bone grafts performed annually. This research focuses on designing and developing personalized 3D-architected scaffolds to enhance bone regeneration in patients with diabetes using computational simulation techniques. These scaffolds are tailored to replicate the mechanical and structural properties of natural bone by optimizing key features such as anisotropy, porosity, and nutrient mass flow. The study highlights the transformative potential of personalized 3D-architected scaffolds in addressing critical challenges associated with diabetic bone health. Customizing scaffold designs to meet the specific needs of patients with diabetes aims to reduce postoperative complications, improve healing outcomes, and enhance overall patient quality of life. Future work will refine scaffold designs and validate their performance in diabetes-specific clinical in vitro and in vivo models.