Despite the huge potential that more inclusive education offers for students, societies, and even the planet, challenges have remained in regard to implementing the reform that is needed to make it a reality. Many have pointed to the dearth between inclusive policy and practice, and hundreds of millions remain excluded—both from education and within education. Particularly in the Global South, harmful stigmas, a lack of teacher training, and poor infrastructure contribute to the physical exclusion of millions from schools. In wealthier nations, too, many students—primarily those that have been historically marginalised—find themselves either unengaged in mainstream schools, or placed in special provision, away from their peers. In this chapter, Mel Ainscow draws on over three decades of experience as he lays out possible pathways for change. Centred on the broad theme that inclusive education must not be seen as a peripheral issue, but must be central to all education policy, Ainscow puts forward six key principles for guiding education reform, all of which are interconnected and emphasise the importance of systemic change. These include the addressing of key barriers, the development of school partnerships, and the importance of local and community efforts. These principles provide the reader with a concise and contextually flexible structure around which to work.