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This study investigated the antibacterial properties of biodegradable 3D-printed scaffolds composed of polylactic acid (PLA) and polycaprolactone (PCL) with silver nanoparticles (AgNPs). The scaffolds were fabricated using fused filament fabrication 3D printing, and their antibacterial efficacy was tested against Staphylococcus aureus (strain B 918). The experimental samples included varying ratios of PLA and PCL, with and without AgNPs. The bacterial adhesion and proliferation were assessed at 4, 6, 24, and 48 h, revealing that scaffolds with AgNPs exhibited significantly reduced bacterial growth compared to controls. At 24 h, bacterial density on PCL30-PLA70-AgNPs was 5.70 ± 0.13 log CFU, significantly lower than the 8.00 ± 0.14 log CFU observed on PCL30-PLA70. Furthermore, degradation tests in simulated body fluid confirmed a correlation between mass loss and bacterial inhibition, suggesting a controlled ion release mechanism. The results demonstrate that the incorporation of AgNPs in PLA/PCL scaffolds creates their antibacterial properties while maintaining biodegradability, making them promising candidates for bone tissue engineering and dental implants.

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Antibacterial Properties of the Biodegradable 3D-Printed PCL/PLA Scaffolds with Silver Nanoparticles

  • 会议论文

  • 发表日期：

    2025年

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  • Oleksandr Oleshko,
  • Khrystyna Berladir,
  • Tetiana Oleshko,
  • Oleksandr Korol,
  • Rǎzvan Pǎcurar

摘要

This study investigated the antibacterial properties of biodegradable 3D-printed scaffolds composed of polylactic acid (PLA) and polycaprolactone (PCL) with silver nanoparticles (AgNPs). The scaffolds were fabricated using fused filament fabrication 3D printing, and their antibacterial efficacy was tested against Staphylococcus aureus (strain B 918). The experimental samples included varying ratios of PLA and PCL, with and without AgNPs. The bacterial adhesion and proliferation were assessed at 4, 6, 24, and 48 h, revealing that scaffolds with AgNPs exhibited significantly reduced bacterial growth compared to controls. At 24 h, bacterial density on PCL30-PLA70-AgNPs was 5.70 ± 0.13 log CFU, significantly lower than the 8.00 ± 0.14 log CFU observed on PCL30-PLA70. Furthermore, degradation tests in simulated body fluid confirmed a correlation between mass loss and bacterial inhibition, suggesting a controlled ion release mechanism. The results demonstrate that the incorporation of AgNPs in PLA/PCL scaffolds creates their antibacterial properties while maintaining biodegradability, making them promising candidates for bone tissue engineering and dental implants.