Following treatment of prosthetic joint infection (PJI), antibiotic-eluting spacers are frequently utilized to fill bone defects left behind after debridement and removal of prior reconstructive components. A variety of spacer types exist and can be utilized in various anatomical locations. The patient’s anatomy, prior surgical history, and medical comorbidities are large aspects in guiding the conversation between physician and patient and the ultimate decision on spacer type. Static spacers provide a good option for patients with severe bone loss, collateral ligament insufficiency, and the absence of a functional extensor mechanism. While articulating spacers have been shown to better maintain joint space, reduce further bone loss, and help preserve joint mobility, they are not suitable for every patient. Articulating spacers require better-preserved anatomy. Studies analyzing the outcomes between static and articulating spacers have consistently found comparable results. The objective of this chapter was to provide a review of the literature that exists on spacers at the knee and hip of patients with PJI, varying anatomy, and complex medical needs to assist surgeons in operative treatment decisions.