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In [23], we put forward the layered-aggregate formation, with alternaing neutral and charged layers, as an intrinsic part of the mechanism of action of the antimicrobial peptides, highlighting the key role of non-cationic components in natural antimicrobial substances. In this study, we explore the impact of the charge location and distribution on the aggregation and bio-dynamics of peptide compositions using a toy model multi-component system of novel low-molecular-weight snail-mucus peptides.

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Toy Model of a Multi-component Antimicrobial Substance with Novel Low-Molecular-Weight Snail-Mucus Peptides

  • 会议论文

  • 发表日期：

    2025年

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  • Nevena Ilieva,
  • Peicho Petkov,
  • Elena Lilkova,
  • Lyudmila Velkova,
  • Petar Petrov,
  • Aleksandar Dolashki,
  • Pavlinka Dolashka,
  • Leandar Litov

摘要

In [23], we put forward the layered-aggregate formation, with alternaing neutral and charged layers, as an intrinsic part of the mechanism of action of the antimicrobial peptides, highlighting the key role of non-cationic components in natural antimicrobial substances. In this study, we explore the impact of the charge location and distribution on the aggregation and bio-dynamics of peptide compositions using a toy model multi-component system of novel low-molecular-weight snail-mucus peptides.