At a global level, the World Health Organization (WHO) and the United Nations Children’s Fund (UNICEF) have jointly led a redesign of the child and adolescent health and well-being agenda to better respond to the needs of children and adolescents in the first two decades of life. The agenda encompasses several strategic shifts, including toward life-course interventions, integrated family-, child-, and adolescent-centered services, and quality and coverage of care with equity through whole-of-government and whole-of-society approaches. This chapter will review recent advances in public health, from a survival agenda for children under five toward a “thrive” agenda focusing on child and adolescent health and well-being. A comprehensive agenda informing the redesign of child and adolescent health and development services will be summarized. This will be followed by a focus on the important role a proposed schedule of child and adolescent well-care visits can play as a platform for delivering integrated child and adolescent health interventions and making connections between essential services in health and other sectors.