Sustainable scaffolds offer efficient temporary support for cellular growth that can continue tissue regeneration for the development of desired organs without any toxic impact on the system in the foreseeable future. Regenerative medicine offers a transformative approach to tissue repair, but conventional scaffolds often raise environmental concerns. In recent years, several approaches have been adopted to incorporate sustainability into the designing of tissue engineering scaffolds during the fabrication process, which is achieved by using biodegradable/biocompatible, natural/synthetic polymers, energy-efficient and solvent-free processes, etc. Recent advancements in designing sustainable scaffolds and their potential use in tissue engineering applications are discussed. This sustainable approach paves the way for a future where promoting human health by reducing morbidity and mortality, goes hand-in-hand with fostering a healthier planet.