Advancements and Applications of 3D Bioprinted Scaffold in Diabetic Wound Healing
摘要
Wound healing presents a significant challenge in healthcare, particularly in cases of diabetic wounds, chronic wounds, burns, and tissue defects. Conventional wound healing methods often fall short in addressing complex wounds, highlighting the urgent need for innovative approaches. In current years, 3D bioprinting has appeared as a promising technology with vast potential in tissue engineering and regenerative medicine. The capability to precisely deposit biomaterials and cells layer by layer offers unprecedented control over scaffold design and composition, making it particularly suitable for creating customized scaffolds tailored to individual patient needs. This review explores the recent advancements and applications of 3D bioprinted scaffolds in diabetic wound healing. We discuss various biological materials used for scaffold fabrication, containing natural polymers, synthetic polymers, and hybrid constructs, emphasizing their bio-compatibility, mechanical properties and degradation kinetics. Additionally, we examine the incorporation of biologically active molecules, growth factors, and stem cells into bioprinted scaffolds to enhance the wound healing processes such as cell proliferation, angiogenesis, and tissue regeneration. Even with the numerous advancements in this sector up to this point, it is still difficult to handle the intricacy of the tissue with the present manufacturing techniques. A review of the characteristics, parameters, and formulations of bioinks are included, along with the current bioprinting techniques. Ultimately, a range of instances and developments in the subject are presented, along with their limits and future directions. Scaffolds are a 3D fabrication that may be used as a template for cell growth and regeneration, avoiding infections and speeding up the diabetic wound healing process.