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Carbonate apatite (CO3Ap) is a promising, non-toxic, biodegradable material for bone replacement and drug delivery, including ibuprofen. Studies involving CO3Ap blocks in laboratory and vacuum environments help determine ibuprofen entrapment efficiency (EE) and drug loading (DL). Testing drug release in Phosphate Buffered Saline (PBS) at pH 7.4 provides valuable data on drug release kinetics, crucial for designing effective delivery systems. These findings inform the optimization of CO3Ap-based drug carriers for future research and development.

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Effect of Drug Loading Method on the Ibuprofen Loaded Carbonate Apatite Block for Bone Substitutes

  • 会议论文

  • 发表日期：

    2025年

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  • Nguyen Xuan Thanh Tram,
  • Nguyen An Thanh Binh

摘要

Carbonate apatite (CO3Ap) is a promising, non-toxic, biodegradable material for bone replacement and drug delivery, including ibuprofen. Studies involving CO3Ap blocks in laboratory and vacuum environments help determine ibuprofen entrapment efficiency (EE) and drug loading (DL). Testing drug release in Phosphate Buffered Saline (PBS) at pH 7.4 provides valuable data on drug release kinetics, crucial for designing effective delivery systems. These findings inform the optimization of CO3Ap-based drug carriers for future research and development.