To reduce uncertainties associated with its structural reassessment, the Zeeland Bridge in the Netherlands is currently the subject of a field lab, which will run for 2 years. In this contribution, numerical investigations to study the dependencies between variables associated with uncertain structural properties of the bridge and various response/measurement quantities are presented. Initial focus is on load testing of the bridge to obtain insight into the possibly varying response in different spans of the bridge. Parametric studies to expose input-output parameter dependencies are performed on a representative subsystem of the bridge, and the results are used to assist in the design of a measurement campaign and the development of a robust model updating strategy for the bridge.