This research focuses on the dynamic behavior of a 26-storey residential skyscraper with a periodic structure, employing a combination of in-situ measurements and modeling techniques. Based on applications of reduced models for existing buildings, we aim to evaluate the effectiveness of generalized beam models for accurately predicting the tower’s dynamic response. Our approach encompasses in-situ measurements of the tower’s response to ambient vibrations, to identify its fundamental transverse and torsional modes, homogenization modeling to determine the macroscopic behavior of the periodic structure, complementing the experimental results with theoretical insights, Finite Element Analysis with static and modal analysis at both the individual level and the building scale for detailed understanding of the structure’s dynamic characteristics. By comparing the results, we evaluate the effectiveness of generalized beam models in capturing the dynamic behavior of this real-world high-rise structure. This investigation highlights the application and limitations of simplified models for structural analysis and design and demonstrates their potential for cost-effective and reliable assessment of existing structures, particularly in earthquake engineering contexts. The study emphasizes the advantages of using ambient vibration measurements for the diagnosis of existing structures, highlighting their robustness and reliability in identifying dominant and negligible phenomena.