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This chapter explored the methodological foundations, clinical applications, and translational potential of NMR-based metabolomics, with a focus on the APOE signature in Alzheimer’s disease. The integration of high-resolution NMR techniques with advanced statistical and bioinformatic tools enables early detection, risk stratification, and monitoring of disease progression. Emerging technologies and interdisciplinary approaches are poised to bridge current gaps, paving the way for routine clinical implementation.

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APOE and Metabolomics Studies

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  • 发表日期：

    2026年

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  • A. M. A. Martins,
  • D. Zampieri,
  • G. Costa dos Santos

摘要

This chapter explored the methodological foundations, clinical applications, and translational potential of NMR-based metabolomics, with a focus on the APOE signature in Alzheimer’s disease. The integration of high-resolution NMR techniques with advanced statistical and bioinformatic tools enables early detection, risk stratification, and monitoring of disease progression. Emerging technologies and interdisciplinary approaches are poised to bridge current gaps, paving the way for routine clinical implementation.