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ApoE is a glycosylated protein with three isoforms in humans: apoE2, apoE3, and apoE4, encoded by the gene APOE ε on the 19th chromosome. It is found in a variety of tissues and has multiple functions. Apart from its lipid properties, APOE can act as a modulator of inflammation and immune responses. It is well-known that cancer cells can acquire traits to evade the immune system and continue to proliferate. In this chapter we examine the role of Apolipoprotein E (apoE) on the immune system with a special focus on the association of APOE ε allele in cancer immunology.

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APOE and Cancer Immunology

  • 工具书词条

  • 发表日期：

    2026年

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  • Raquel Carvalho Montenegro,
  • Pedro Filho Noronha de Souza,
  • Felipe Pantoja Mesquita

摘要

ApoE is a glycosylated protein with three isoforms in humans: apoE2, apoE3, and apoE4, encoded by the gene APOE ε on the 19th chromosome. It is found in a variety of tissues and has multiple functions. Apart from its lipid properties, APOE can act as a modulator of inflammation and immune responses. It is well-known that cancer cells can acquire traits to evade the immune system and continue to proliferate. In this chapter we examine the role of Apolipoprotein E (apoE) on the immune system with a special focus on the association of APOE ε allele in cancer immunology.