Synthetic polymer-based additive manufacturing holds significant promise for regenerative medicine and tissue engineering, enabling the creation of customized scaffolds and implants. These scaffolds, essential for tissue regeneration, provide structural support and promote cellular activity. Factors such as chemical composition, biodegradability, and physical properties are crucial in scaffold design, impacting cell adhesion, proliferation, and differentiation. Polymers, both natural (e.g., collagen, hyaluronic acid) and synthetic (e.g., PLA, PCL), are widely used due to their favourable characteristics. Additive manufacturing techniques, including fused deposition modelling (FDM), stereolithography (SLA), and selective laser sintering (SLS), allow precise control over scaffold architecture, enhancing their suitability for specific tissue types. However, challenges remain, such as achieving the optimal balance between scaffold biodegradability and mechanical stability. The chapter explores the potential of biopolymers and biodegradable synthetic polymers in creating lightweight, sustainable materials for biomedical applications. It also addresses the need for advancements in material properties and manufacturing techniques to meet the complex requirements of tissue engineering. Future research directions include improving the biocompatibility and functional integration of these scaffolds to enhance their clinical applicability.